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Pathological states are the consequence of several determinate factors acting simultaneously. . . The manifestations of any given agent differ profoundly from one person to another. . . . Each noxious agent can express itself by a great variety of different pathological states. . . . Different agents can elicit similar reactions. . . . The total environment and the (interior medium) constitute a multifactorial system.

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Horace

An envious man grows lean at another's fatness.