What works for me is that I read widely and stay focused on my writing. I'm no longer concerned about what happens in the literary marketplace. It is distracting and can lead to discontent.
Death is a big theme in the book, illness. What is that? It's a fact that human beings - no matter who they are, no matter how healthy or strong or beautiful they are - are going to age and become weak and ugly by a certain standard, and die. And I think that's a terrifying idea for people to get their minds around.