If you love, absolutely love what you are doing, chances are excellent that you will succeed. There is nothing so exhausting as working on a job you don't like.
It is amazing that 2001: A Space Odyssey has not aged at all, except for a few minor technical gadgets. The main reason is, of course, the philosophical or spiritual element in this story. We know as little today about the secrets of Creation and evolution as we knew before, and it is not likely that we'll ever know much more. We'll have to be satisfied, as Kubrick was, respectfully admiring the potential for evolution within the mystery of the universe's creation.