It takes a fearless, unflinching love and deep humility to accept the universe as it is. The most effective way he knew to accomplish that, the most powerful tool at his disposal, was the scientific method, which over time winnows out deception. It can't give you absolute truth because science is a permanent revolution, always subject to revision, but it can give you successive approximations of reality.
I think we are all overcoming tiny obstacles every second of every day even if that means just a small shift in perspective.