Whatever the best scripts are and you just want to play roles that you can really sink your teeth into. That's always the goal no matter if it's a good guy or a bad guy, or a comedy, or a drama. It doesn't matter, you just want something that's substantial you can sink your teeth into and that you haven't done before, something that's really going to challenge you.
Woody Allen would go for seven years without a movie and then make one that makes no money.