The enemy resembles us. Therefore, he needs to be approached not as an assembly of 'targets' to be destroyed one by one; but as a living, intelligent entity capable of acting and reacting.
Manhattan's always fascinating, too, just a big, stinky, smelly conglomeration of numbered avenues and streets, but it's just got a vibe that's hard to beat. I shouldn't like it, but I do. I can't put my finger on it.